Wisconsin has some of the most scenic river towns you’ll find along the Mississippi River. Prescott was built at the juncture of the St. Croix and Mississippi Rivers. Wisconsin’s second oldest community, Prairie du Chien, was built near the confluence of the Wisconsin and Mississippi Rivers. Alma and Fountain City stretch along a narrow plain at the base of tall bluffs. Old river towns like Trempealeau and Ferryville maintain strong ties to the river today. The biggest city, La Crosse, is a vibrant college town in a region of about 100,000 people. The drive along Wisconsin’s Great River Road follows a scenic, two-lane highway, where it’s easy to take your time to explore.